PATHWAY-27 includes 25 partners broadly distributed in Europe: west to east, south to north Europe, including one Candidate Country (Turkey). The EU Consortium consists of different organisation types, namely: Universities, Research Institutes and SMEs.
The Deutsches Krebsforschungszentrum (German Cancer Research Center, DKFZ) enjoys a worldwide reputation for excellence in basic and translational cancer research, highlighted by the 2008 Nobel Prize for medicine to Harald zur Hausen. Founded in 1964, the DKFZ has nowadays a staff of 2300 persons, with more than 1040 scientists and approximately 1015 employees providing administrative and technical support. The research programme is concentrated on seven main research areas: signalling pathways, cell biology and cancer; structural and functional genomics; cancer risk factors and prevention; tumour immunology; innovative diagnosis, prevention and therapy; infection and cancer; and translational cancer research. . DKFZ has a strong record of participation in EU framework programmes. Within FP6 DKFZ is participating in about 60 projects with funding for the DKFZ of 24 Mio. €. Within FP7 DKFZ is participating in 31 projects with funding for the DKFZ of approx. 20 Mio. €.
Previous experience related to the tasks. Epigenetic characterization of major malignancies by using genome-wide screens for the identification of aberrant DNA methylation, characterization of candidate genes identified as epigenetic targets, elucidation of mechanisms of epigenetic gene regulation, development of mouse models relevant for epigenetic studies, development of novel biomarkers relevant for chemoprevention, early diagnosis and treatment response.
Analyses of early epigenetic changes (DNA methylation, histone acetylation) during carcinogenesis and the influence of dietary factors on these changes in cell culture, in animal models and in human intervention studies (nutri-epigenomics). State-of-the-art technology for quantitative methylation analysis, including MassARRAY technology based on MALDI-TOF mass spectrometry, methyl-CpG immunoprecipitation (MCIp) coupled with CpG island microarray analyses and next generation sequencing, quantitative real time PCR analysis, flow cytometry, siRNA and shRNA technology, demethylating agents for functional analyses.
Scientific responsible: Clarissa Gerhäuser (firstname.lastname@example.org)
The University of Leeds is one of the largest higher education institutions in the UK and a member of the Russell Group of research-intensive universities. The 2008 Research Assessment Exercise confirmed the University as one of the top ten research institutions with departments undertaking research of national and international excellence. These demonstrate and ensure that the University is able to provide a service which meets the needs of all stakeholders whilst conforming with all applicable legal and statutory requirements. Audits are undertaken annually to monitor compliance with these policies and procedures. The School of Food Science and Nutrition at UL has strong research expertise in functional foods, food structure, food processing, nutrition, ethnic foods and epidemiology, and collaborates with leading organisations in nationally-, European- and industry- funded projects, including EuroFIR, the world–leading NoE on Food Composition Databank systems.
The School has high quality staff and sophisticated, state-of- the-art facilities to support its research programme. In particular, it has modern standardised food technology laboratory.
Scientific responsible: Santosh Khokhar (email@example.com)
The Mandrup Group (http://www.sdu.dk/mandrupgroup) is located at Department of Biochemistry and Molecular Biology at University of Southern Denmark. The group focuses on understanding the transcriptional network regulating adipocyte differentiation and in the molecular cross-talk between transcriptional regulation and metabolism in mammalian cells, in particular adipocytes and pancreatic β-cells. The group combines genome-wide studies mapping factor binding, epigenetic marks and chromatin structure with detailed molecular analyses of the cross-talk between transcriptional regulators. . The group is particularly interested in the function, regulation and mechanism of action of peroxisome proliferator activated receptors (PPARs) and in the transcriptional network controlling adipocyte differentiation. In addition, the Mandrup laboratory has a long-standing interest in lipid binding proteins and has generated mice with targeted disruption of the acyl-CoA binding protein (ACBP).
Scientific responsible: Susanne Mandrup (firstname.lastname@example.org)
AINIA is a technological research centre focused in the agro-food sector and related industries with more than 1100 associated companies. Ainia's mission is to promote research and technological development in the agrofood sector, to increase the quality of production, improve competitiveness and promote modernisation and diversification in the agro-food industries, through the execution of scientific research projects and public or private technological development.
Previous experience related to the tasks. Evaluation the biological effect of food and food ingredient on different metabolic pathway, in relation to health and prevention of disease risk. In vitro studies based on cell cultures .Development and innovation of food product Formulation and improvement of nutritional properties, new ingredients for the reformulation of food products, amongst others. In vitro studies of bioavailability and capacity for nutrient absorption by an artificial in vitro digestive system. Experience in quality control and food safety. Detection, control and characterization of spoilage microorganisms and foodborne pathogens by classical methods based on molecular biology. Food testing, nutritional and functional parameters. Moreover, legislative routine analyses are daily performed such as micotoxines, pesticides and antibiotics residues, heavy metals, etc. Development of information portals and collaborative web-based tools. Integration of distributed electronic data sources.. Food chain requirements analysis and information model development. Design of decision support tools.
Scientific responsible: Lidia Tomás Cobos (email@example.com)
The CRNH Auvergne brings together 6 research units including 17 research teams and a Nutrition Investigation Platform (NIP) dedicated to interventional studies in volunteers. CRNH Auvergne research area is the prevention of physiological dysfunctions in elderly and of chronic diseases. CRNH Auvergne is one of the world leading centres for protein and polyphenol metabolism. Research is oriented towards the prevention of sarcopenia, osteoporosis, degenerative cardiovascular diseases, gut microflora, digestive pain and hormone dependent cancers. The NIP surface is approximately 400 m2. It contains 7 beds for one-day investigations, including 2 beds for the more invasive ones. NIP staff includes 2 nurses, 2 dieticians, 2 clinical research assistants, 1 cooker, one secretary, and 3 MDs. The NIP makes it possible to explore body composition (BIA, DEXA, CT-scan, MRI), energy metabolism, protein metabolism using whole-body and regional tracer kinetics, insulin sensitivity, non-energy nutrient effects. This NIP is remarkable by the presence of an experimental kitchen and two calorimetric chambers.
Scientific responsible: Noel J Cano (firstname.lastname@example.org)
The collaborative workspace is for the PATHWAY-27 project partners. You are welcome!